RELAPSED/REFRACTORY MULTIPLE MYELOMA-TRANSFORMED PLASMA-CELL LEUKEMIA SUCCESSFULLY TREATED WITH DARATUMUMAB FOLLOWED BY AUTOLOGOUS STEM CELL TRANSPLANTATION

Daratumumab is a humanized anti-CD38 IgG1 monoclonal antibody which could be used for multiple myeloma (MM).MM with plasma-cell leukemia (PCL) transformation is highly aggressive and is resistant to conventional therapy.Novel therapeutics are needed for PCL, and daratumumab may play role.We report a case of relapsed/refractory multiple myeloma (RRM

BACKGROUND: Gene expression profiles of bacteria in their natural hosts can provide novel insight into the host-pathogen interactions and molecular determinants of bacterial infections.In the present study, the transcriptional profile of the porcine lung pathogen Actinobacillus pleuropneumoniae was monitored during the acute phase of infection in i

A variety of circumstances contribute to an increasingly large number of minors who leave family, home, and country to seek asylum on Cable foreign soil.They present special challenges to state and local authorities, to relevant non-governmental agencies, and to the international community.This paper considers the planning needs for these Arm Sling

Objective: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder diagnosed in increasing proportions of children and adolescents.The psychostimulant methylphenidate has been considered the first-line pharmacological Bun Pan Carriers treatment for children and adolescents with ADHD for more than 60 years.Considering recent